Uniqueness of iterative positive solutions for the singular infinite-point p-Laplacian fractional differential system via sequential technique

By sequential techniques and mixed monotone operator, the uniqueness of positive solution for singular p-Laplacian fractional differential system with infinite-point boundary conditions is obtained. Green's function is derived, and some useful properties of Green' function are obtained. Based on these new properties, the existence of unique positive solutions is established, moreover, an iterative sequence and a convergence rate are given, which are important for practical application, and an example is given to demonstrate the validity of our main results

Multiphase flow dynamics and mass transfer in different multiphase reactor for shear controllable synthesis process

In short, this thesis gives insight in detailed particle synthesis process modelling in two main multiphase reactors (IJR and SVFR) and experiments of synthesis of FePO4 and SiO2 aggregated particles are performed to analysis effect of hydrodynamics on particle properties. The attempt of combination of fast-mixer and external ultrasound field in micro/nano-particle synthesis has successfully intensified turbulence and such combination has positive effects on aspects of chemical reaction, mixing performance and mass transfer. Except for experimental work, the simulation work has been carried out to analyse flow patterns, turbulent intensity, chemical reaction as well as particle fluid interaction in particle synthesis process in multiphase reactors. Such investigation makes it possible to build correlations on hydrodynamic parameters and particle characteristics and helps to predict the behaviour and properties of particles. This is meaningful for design, upgrade and scale-up of multiphase reactor in synthesis process

Multiphase flow dynamics and mass transfer in different multiphase reactor for shear controllable synthesis process

In short, this thesis gives insight in detailed particle synthesis process modelling in two main multiphase reactors (IJR and SVFR) and experiments of synthesis of FePO4 and SiO2 aggregated particles are performed to analysis effect of hydrodynamics on particle properties. The attempt of combination of fast-mixer and external ultrasound field in micro/nano-particle synthesis has successfully intensified turbulence and such combination has positive effects on aspects of chemical reaction, mixing performance and mass transfer. Except for experimental work, the simulation work has been carried out to analyse flow patterns, turbulent intensity, chemical reaction as well as particle fluid interaction in particle synthesis process in multiphase reactors. Such investigation makes it possible to build correlations on hydrodynamic parameters and particle characteristics and helps to predict the behaviour and properties of particles. This is meaningful for design, upgrade and scale-up of multiphase reactor in synthesis process

A Review of the Ninth Forum of World Association for Political Economy

The traditional outlook on development is based on expanding physical production, which takes for granted that all economic growth is a good thing and ignores social development. It argues that gross domestic product (GDP) is the sole benchmark for evaluating different countries' economic performances. Such an outlook appears as the reflection of overweighed instrumental rationality and absent human values. On the contrary, a scientific outlook on development, based on Marxist economics, could be taken as a positive response to the shortcomings of the traditional outlook. It argues that scientific economic development should serve the people, and as a consequence, economic development should enhance comprehensive human development and elevate the well-being of the people, eventually improving the livelihoods of people worldwide and the fairness of economic development and income distribution. In May 2014, World Association for Political Economy (WAPE) held its Ninth Forum themed “Growth, Development, Social Justice.” At the forum, participants put out “A Fair Development” and suggested that all countries should put more emphasis on qualitative not just quantitative changes in the economy and consider the basic purpose of economic growth

Prefix-diffusion: A Lightweight Diffusion Model for Diverse Image Captioning

While impressive performance has been achieved in image captioning, the limited diversity of the generated captions and the large parameter scale remain major barriers to the real-word application of these systems. In this work, we propose a lightweight image captioning network in combination with continuous diffusion, called Prefix-diffusion. To achieve diversity, we design an efficient method that injects prefix image embeddings into the denoising process of the diffusion model. In order to reduce trainable parameters, we employ a pre-trained model to extract image features and further design an extra mapping network. Prefix-diffusion is able to generate diverse captions with relatively less parameters, while maintaining the fluency and relevance of the captions benefiting from the generative capabilities of the diffusion model. Our work paves the way for scaling up diffusion models for image captioning, and achieves promising performance compared with recent approaches.Comment: 11 pages,4 figures, 6 table

Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK.

Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling. The current study investigated whether PreCon with inhaled anesthetic sevoflurane (SF-PreCon) remains cardioprotective during DM, and identified the involved mechanisms. Normal diet (ND) and high-fat diet (HFD)-induced DM mice were randomized into control and SF-PreCon (3 cycles of 15-minute period exposures to 2% sevoflurane) groups before MI/R. SF-PreCon markedly reduced MI/R injury in DM mice, as evidenced by improved cardiac function (increased LVEF and ±Dp/dt), decreased infarct size, and decreased apoptosis. To determine the relevant role of AMPK, the effect of SF-PreCon was determined in cardiac-specific AMPKα2 dominant negative expressing mice (AMPK-DN). SF-PreCon decreased MI/R injury in AMPK-DN mice. To explore the molecular mechanisms responsible for SF-PreCon mediated cardioprotection in DM mice, cell survival molecules were screened. Interestingly, in ND mice, SF-PreCon significantly reduced MI/R-induced activation of p38, a pro-death MAPK, without altering ERK and JNK. In DM and AMPK-DN mice, the inhibitory effect of SF-PreCon upon p38 activation was significantly blunted. However, SF-PreCon significantly increased phosphorylation of ERK1/2, a pro-survival MAPK in DM and AMPK-DN mice. We demonstrate that SF-PreCon protects the heart via AMPK-dependent inhibition of pro-death MAPK in ND mice. However, SF-PreCon exerts cardioprotective action via AMPK-independent activation of a pro-survival MAPK member in DM mice. SF-PreCon may be beneficial compared to conventional PreCon in diabetes or clinical scenarios in which AMPK signaling is impaired

The Prospects for Immigration Amendments

Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and stringent response. Here, using pre-steady state fast kinetics we demonstrate that ObgE is an anti-association factor, which prevents ribosomal subunit association and downstream steps in translation by binding to the 50S subunit. ObgE is a ribosome dependent GTPase; however, upon binding to guanosine tetraphosphate (ppGpp), the global regulator of stringent response, ObgE exhibits an enhanced interaction with the 50S subunit, resulting in increased equilibrium dissociation of the 70S ribosome into subunits. Furthermore, our cryo-electron microscopy (cryo-EM) structure of the 50S? ObgE? GMPPNP complex indicates that the evolutionarily conserved N-terminal domain (NTD) of ObgE is a tRNA structural mimic, with specific interactions with peptidyl-transferase center, displaying a marked resemblance to Class I release factors. These structural data might define ObgE as a specialized translation factor related to stress responses, and provide a framework towards future elucidation of functional interplay between ObgE and ribosome-associated (p) ppGpp regulators. Together with published data, our results suggest that ObgE might act as a checkpoint in final stages of the 50S subunit assembly under normal growth conditions. And more importantly, ObgE, as a (p) ppGpp effector, might also have a regulatory role in the production of the 50S subunit and its participation in translation under certain stressed conditions. Thus, our findings might have uncovered an under-recognized mechanism of translation control by environmental cues